Absorbable hemostatic materials are medical devices designed to control bleeding during surgical procedures, especially when conventional methods are ineffective. These absorbable hemostatic materials accelerate the local coagulation process by providing a scaffold that facilitates the body's natural hemostatic mechanisms. Key characteristics of absorbable hemostatic materials include rapid hemostasis, biodegradability, minimal foreign body reactions, elimination of the need for removal surgeries, and reduced patient trauma. This article will introduce the mechanism of absorbable hemostatic materials, absorbable hemostatic product forms, market analysis of absorbable hemostatic materials products and so on.
Classification of Hemostatic Mechanisms
Hemostatic materials can be categorized based on their functional characteristics into four primary types:
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Hemostatic Materials Types |
Hemostatic Mechanisms |
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Physical Hemostasis |
These materials act by forming a barrier that halts blood flow and provides a surface that promotes rapid clot formation. |
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Biological Hemostasis |
Utilizes concentrated thrombin to convert fibrinogen into fibrin clots, facilitating coagulation. |
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Combination Hemostasis |
Integrates physical barriers with thrombin to both block blood flow and actively promote fibrin formation. |
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Fibrin Glue Hemostasis |
Delivers high concentrations of fibrinogen and thrombin directly to the bleeding site, enhancing clot formation rates. |
Product Forms and Structural Classifications
Absorbable hemostatic materials encompass a variety of substances, including thrombin, gelatin, collagen, fibrin, cellulose, and polysaccharides like starch and chitosan. These are manufactured in forms such as sponges, powders, gels, and gauze.
Fibrous and Nonwoven Materials vs. Gauze: Fibrous and nonwoven hemostatic materials possess a more porous and fluffy structure compared to traditional gauze, resulting in larger contact areas with bleeding sites. This structure allows for faster absorption rates and more effective hemostasis.
Powdered Materials for Minimally Invasive Surgery: With the rise of minimally invasive procedures, powdered hemostatic agents have become increasingly valuable. Their fine particulate nature allows for easy application through narrow channels used in endoscopic and laparoscopic surgeries, making them ideal for confined surgical spaces.
High-Performance Absorbable Hemostatic Products
Absorbable hemostatic materials encompass a variety of substances, including thrombin, gelatin, collagen, fibrin, cellulose, and polysaccharides like starch and chitosan. These are manufactured in forms such as sponges, powders, gels, and gauze.
Fibrin Glue: Combines fibrinogen and thrombin to activate the coagulation cascade. However, it requires cold storage and pre-use warming, and the clot formation process takes 1–2 minutes, making it less suitable for rapid arterial bleeding scenarios.
Absorbable Gelatin-Based Hemostats: Comprising fluid gelatin and thrombin, these are applied using long applicators. If not adequately removed post-hemostasis, they may cause local edema or, if inadvertently introduced into blood vessels, can lead to thrombosis, anemia, infection, or bleeding.
Oxidized Regenerated Cellulose (ORC) Hemostats: Products like Johnson & Johnson's SURGICEL™ are notable examples. ORC can be quickly applied, easily shaped, and firmly adheres to wound sites, maximizing the hemostatic surface area. Its plant-derived origin ensures complete biodegradability into glucose, offering superior safety, biocompatibility, and non-pyrogenicity compared to animal-derived hemostatic powders. Additionally, the carboxyl groups in ORC confer broad-spectrum antibacterial properties and enhance hemostatic efficacy by binding to hemoglobin.Market Analysis of Absorbable Hemostatic Materials
The global market for absorbable hemostatic materials experienced a significant rebound post-2021, reaching approximately ¥21.9 billion (RMB). China's market trends align with global patterns but exhibit higher growth rates. With the resumption of elective surgeries following the pandemic, global demand for absorbable hemostatic materials is on the rise. Projections indicate that by 2026, the global market will reach ¥32 billion, with China's market expected to hit ¥5.1 billion.
Market Analysis of Absorbable Hemostatic Materials
Currently, absorbable hemostatic gauze dominates the global market, accounting for 30% of sales. In China, this category holds a 66% market share. However, as domestic technologies advance, China's product distribution is gradually aligning with global standards.
Conclusion
Absorbable hemostatic materials are gradually becoming one of the indispensable medical devices in modern surgeries. As a professional supplier of hemostatic products, Surgiclean has always been committed to developing high-performance and highly adaptable hemostatic solutions to meet the ever-changing clinical needs. In the future, with the increase in the popularity of minimally invasive surgery and the acceleration of the localization of medical consumables, the absorbable hemostatic material market will usher in a broader development space.